Publications by authors named "Jonathan Gardiner"
PAMAM dendrimers for the delivery of the antibacterial Triclosan.
J Enzyme Inhib Med Chem
October 2008
Many oral care products incorporate an antibacterial compound to prevent the formation of dental plaque which predisposes teeth to dental caries or periodontal disease. Triclosan (TCN) is a commonly used antiplaque agent in toothpastes. Strategies to increase the delivery efficiency of antibacterials using formulation aids such as polyamidoamine (PAMAM) dendrimers are of interest.
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- A small but notable number of total knee replacements experience a problem called aseptic loosening, which isn't usually caused by polyethylene debris.
- Although allergic reactions to polymethylmethacrylate bone cement are rare, they can lead to significant issues like inflammation, pain, and loosening of the knee replacement.
- A specific case is discussed where a patient suffered severe pain after knee surgery due to hypersensitivity to benzoyl peroxide, a component of the bone cement used.