Publications by authors named "Jonathan Freshman"
Article Synopsis
- Early antiviral treatments like intravenous remdesivir (RDV) have shown promise in reducing severe COVID-19 cases, and an oral form of RDV may allow for earlier treatment in non-hospitalized patients.
- Researchers synthesized and evaluated oral analogs of RDV that are stable in plasma, specifically a compound named 1-octadecyl-2-benzyl-glyceryl-3-RVn, which effectively reduced viral load in infected mice.
- The study indicates that modifications, such as adding specific substituents to the analogs, can enhance antiviral activity, supporting further development of these compounds as effective oral treatments for SARS-CoV-2.
Article Synopsis
- Metastases in solid tumors rely on tumor cells traveling through the bloodstream, which complicates patient prognosis and requires the cells to pass through blood vessel walls.
- The study screened over 3,500 compounds to find drugs that prevent tumor cells from moving through blood vessels, identifying 38 potential candidates, specifically highlighting niclosamide for its ability to strengthen the endothelial barrier and decrease tumor cell movement.
- Niclosamide was further validated in zebrafish and mouse models, showing significant reduction in tumor cell movement and metastasis, while affecting key signaling pathways between tumor and endothelial cells that regulate their interactions.
Through multiple cell-cell and cell-matrix interactions, epithelial and endothelial sheets form tight barriers. Modulators of the cytoskeleton contribute to barrier stability and act as rheostats of vascular permeability. In this study, we sought to identify cytoskeletal regulators that underlie barrier diversity across vessels.
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