Publications by authors named "Jonathan Fernando Reinoso-Sanchez"

Article Synopsis
  • * The study aimed to examine histone acetylation in RDEB skin and to evaluate the potential of histone deacetylase inhibitors (HDACi) like givinostat and valproic acid (VPA) as treatments to reduce fibrosis and disease advancement in RDEB models.
  • * Findings indicated that decreased histone acetylation is present in RDEB skin, and treating RDEB fibroblasts with HDACi reduced fibrotic behavior; VPA treatment in RDEB mice improved symptoms related to
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Article Synopsis
  • Skeletal muscle atrophy is a medical condition that currently lacks effective treatments and is not well understood at the molecular level, with emerging research highlighting the role of circular RNAs (circRNAs) in muscle development and related diseases.
  • The study focuses on spermine oxidase (SMOX), a critical enzyme for muscle differentiation, analyzing both circular and linear forms of SMOX during muscle cell development and in models of muscle atrophy induced by dexamethasone.
  • Findings reveal that while both forms of SMOX have a similar expression pattern during normal muscle development, circSMOX levels significantly increase during atrophy, suggesting its potential as a new target for treatment of muscle atrophy.
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