Publications by authors named "Jonathan David Roth"
Article Synopsis
- - The study evaluated how well liver biopsy analyses reflect overall liver changes during drug treatments for nonalcoholic steatohepatitis (NASH) in specially bred mice fed a high-fat diet.
- - Male Lep/Lep mice were treated with various compounds, showing that while some drugs reduced liver weight and lipid levels, one drug (elafibranor) unexpectedly increased liver size.
- - The results indicated that different compounds affected liver health metrics like inflammation and fibrosis variably, and notable histological improvements were observed, particularly with treatments like INT-767 and liraglutide.
Aim: To characterize development of diet-induced nonalcoholic steatohepatitis (NASH) by performing liver biopsy in wild-type and genetically obese mice.
Methods: Male wild-type C57BL/6J (C57) mice (DIO-NASH) and male Lep(ob) /Lep(ob) (ob/ob) mice (ob/ob-NASH) were maintained on a diet high in trans-fat (40%), fructose (22%) and cholesterol (2%) for 26 and 12 wk, respectively. A normal chow diet served as control in C57 mice (lean chow) and ob/ob mice (ob/ob chow).