A brief history of Guinea worm research in the modern period, 1698-1931.

Guinea worm is a debilitating waterborne parasitic disease with a long history. This paper examines the ways guinea worm was understood in English-language scientific literature between 1688 and 1931. In the early eighteenth century, guinea worm was principally understood by English-speaking physicians as an exotic wonder of faraway lands.

Participating in eradication: how Guinea worm redefined eradication, and eradication redefined Guinea worm, 1985-2022.

Guinea worm disease (dracunculiasis) is a debilitating waterborne disease. Once widespread, it is now on the brink of eradication. However, the Guinea Worm Eradication Programme (GWEP), like guinea worm itself, has been under-studied by historians.

A Rare but Deadly Complication of Transcatheter Aortic Valve Replacement.

We present a rare case of delayed coronary artery obstruction following a transcatheter aortic valve replacement (TAVR). Interestingly, the patient did not meet the criteria for traditionally recognized risk factors for delayed coronary obstruction. This case piques interest as to whether the severity of calcification on aortic valve leaflets plays any role in coronary obstruction post transcatheter aortic valve replacement.

Insight into Cellular Uptake and Transcytosis of Peptide Nanoparticles in Cells and Isolated Midgut.

Silencing genes in insects by introducing double-stranded RNA (dsRNA) in the diet holds promise as a new pest management method. It has been demonstrated that nanoparticles (NPs) can potentiate dsRNA silencing effects by promoting cellular internalization and protecting dsRNA against early degradation. However, many mysteries of how NPs and dsRNA are internalized by gut epithelial cells and, subsequently, transported across the midgut epithelium remain to be unraveled.

A Study of the Cellular Uptake of Magnetic Branched Amphiphilic Peptide Capsules.

Understanding cellular uptake mechanisms of nanoparticles with therapeutic potential has become critical in the field of drug delivery. Elucidation of cellular entry routes can aid in the dissection of the complex intracellular trafficking and potentially allow for the manipulation of nanoparticle fate after cellular delivery (i.e.