Publications by authors named "Jonathan D Cartledge"
Diffuse White Matter Signal Abnormalities on Magnetic Resonance Imaging Are Associated With Human Immunodeficiency Virus Type 1 Viral Escape in the Central Nervous System Among Patients With Neurological Symptoms.
Clin Infect Dis
April 2017
Article Synopsis
- HIV-1 can independently replicate in the central nervous system, leading to conditions known as cerebrospinal fluid (CSF) discordance and escape, which may be linked to neurological symptoms in patients.
- A study involving 146 HIV-infected adults found that 14.7% of cases showed CSF discordance, with some patients experiencing CSF escape despite suppressed plasma viral loads.
- Diffuse white matter signal abnormalities on brain scans were significantly associated with both CSF discordance and escape, indicating the need for further investigation in patients presenting with neurological issues.
White matter (WM) abnormalities are frequently seen on brain MRI of HIV positive (HIV+) patients. We aimed to determine the prevalence of unexplained WM abnormalities and their associations with HIV disease and cardiovascular risk factors. We conducted a retrospective, cross-sectional study of brain MRI of HIV+ patients conducted between 2004 and 2009 at our center.
View Article and Find Full Text PDFThe field of HIV medicine has changed rapidly in the last two decades since effective and tolerable antiretroviral treatment became available. As a result, although classical opportunistic infections of the brain have become less common, clinicians need to be aware of a wider range of acute and chronic complications of HIV and its treatment. In this article, we summarise major opportunistic infections, immune reconstitution inflammatory syndrome, HIV-associated neurocognitive disorders, and cerebrovascular disease in HIV positive patients.
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