Publications by authors named "Jonathan Cahueau"
Article Synopsis
- The human central nervous system (CNS) has a diverse immune compartment that includes various cell populations, notably microglia (brain macrophages) and CNS-associated macrophages (CAMs), which are less common and not well studied.
- Researchers used advanced techniques like single-cell RNA sequencing and spatial transcriptomics to analyze over 356,000 transcriptomes from 102 individuals, revealing insights into the presence and variability of CAM subclasses in different conditions.
- The study also examined myeloid cell types in glioblastoma samples, finding that the immune responses to hypoxia differ significantly between cancer-affected areas and healthy brain regions, emphasizing the complexity of the brain's immune system.
Glioblastomas are the most common primary brain tumors. Despite extensive clinical and molecular insights into these tumors, the prognosis remains dismal. While targeted immunotherapies have shown remarkable success across different non-brain tumor entities, they failed to show efficacy in glioblastomas.
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