Management of neonatal ovarian cysts and its effect on ovarian preservation.

Background/purpose: Management of asymptomatic neonatal ovarian cysts varies. Some surgeons advocate initial observation, while others recommend immediate operation depending on cyst size and complexity. This study aims to compare outcomes of initial observation versus primary surgery, focusing on incidence of postnatal torsion and ovarian preservation.

Postoperative opioid analgesic use after Nuss versus Ravitch pectus excavatum repair.

Background/purpose: Anticipated postoperative pain may affect procedure choice in patients with pectus excavatum. This study aims to compare postoperative pain in patients undergoing Nuss and Ravitch procedures.

Methods: A 5year retrospective review was performed.

Referring physicians' decision making for pediatric anti-reflux procedures.

Background: Rates of anti-reflux procedures (ARP) vary greatly among pediatric hospitals. How pediatric subspecialists make referral decisions for ARPs has not been described. The aim of this study was to characterize pediatric subspecialists' decision making for referring children for ARPs.

Predictors of ovarian malignancy in children: overcoming clinical barriers of ovarian preservation.

Background/purpose: Ovarian preservation is desirable in girls with benign ovarian masses. We aimed to 1) identify clinical predictors of malignant ovarian masses, 2) investigate how often ovarian tissue is present to preserve in benign masses, and 3) identify factors associated with successful ovarian preservation.

Methods: Retrospective analysis (1997-2012) of girls age 1-18years with an ovarian mass managed operatively.

Movement-evoked hyperalgesia induced by lipopolysaccharides is not suppressed by glucocorticoids.

Systemic exposure to lipopolysaccharides (LPS) produces a variety of effects, including movement-evoked hyperalgesia that can be measured using the grip force assay in mice. Because both lethality and enhanced sensitivity to cutaneous pain following exposure to endotoxins have each been attributed to inflammatory mediators, we explored the possibility that LPS-induced movement-evoked hyperalgesia is also sensitive to manipulations of glucocorticoids that regulate these other LPS responses. We found that the hyperalgesic effect of LPS (5mg/kg s.