Publications by Jonathan B Murray | LitMetric

Publications by authors named "Jonathan B Murray"

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Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts.

Jonathan B Murray Christy Mikhael Guanghong Han Lorraine Perciliano de Faria Wellington J Rody

Sci Rep

April 2021

Article Synopsis

The (pro)renin receptor (PRR) is a protein involved in activating (pro)renin and is part of the vacuolar H-ATPase complex, showing high presence in extracellular vesicles from osteoclasts.
Researchers found that extracellular vesicles from osteoclasts stimulate (pro)renin activity in a dose-dependent manner, while those from cancer cells lacking PRR do not.
The stimulation of (pro)renin by osteoclast-derived extracellular vesicles is confirmed to depend on PRR activity, indicating a new way these vesicles may regulate cell communication related to bone biology.

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