Publications by authors named "Jonas Wizenty"

Helicobacter pylori colonizes the human gastric mucosa and persists lifelong. An interactive network between the bacteria and host cells shapes a unique microbial niche within gastric glands that alters epithelial behavior, leading to pathologies such as chronic gastritis and eventually gastric cancer. Gland colonization by the bacterium initiates aberrant trajectories by inducing long-term inflammatory and regenerative gland responses, which involve various specialized epithelial and stromal cells.

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Introduction: Helicobacter pylori colonizes the human stomach. Infection causes chronic gastritis and increases the risk of gastroduodenal ulcer and gastric cancer. Its chronic colonization in the stomach triggers aberrant epithelial and inflammatory signals that are also associated with systemic alterations.

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Article Synopsis
  • The study focuses on the stomach corpus epithelium, which consists of glands and pits, and explores how R-spondin 3 (RSPO3) regulates cell behavior and differentiation in this area.
  • RSPO3 promotes the differentiation of secretory cells into parietal and chief cells while its absence leads to the development of pit cells; high levels of RSPO3 are needed to initiate a regenerative response after cell loss.
  • However, during chronic Helicobacter pylori infection, RSPO3-driven regeneration results in excessive gland growth and increased risk of premalignant changes.
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Article Synopsis
  • Helicobacter pylori is a pathogen that causes chronic gastritis by colonizing deep in the stomach, leading to increased R-spondin 3 (Rspo3) signaling and gland hyperplasia.
  • Lgr4 plays a crucial role in regulating Lgr5 expression, necessary for H. pylori-induced hyperplasia and inflammation, while Lgr5 alone does not drive this process.
  • R-spondin signaling through Lgr4 enhances stem cell proliferation and activates NF-κB, linking epithelial stem cell behavior with inflammatory responses during H. pylori infection.
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() are gram-negative bacteria that are able to colonize and persist in the stomach. Gastric cancer is tightly linked to chronic infection with this bacterium. Research over the last decades has illuminated the molecular interactions between and host cells.

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The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free assessment and visualization of cells and tissues of the human body. While AF imaging (AFI) is well-established in ophthalmology, its clinical applications are steadily expanding to other disciplines. This review summarizes clinical advances of AF techniques published during the past decade.

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Background: Fibronectin type III domain-containing () proteins fulfill manifold functions in tissue development and regulation of cellular metabolism. was described as anti-inflammatory factor, upregulated in inflammatory bowel disease (IBD). signaling includes direct cell-cell interaction as well as release of bioactive peptides, like shown for or .

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Background & Aims: Prolonged preoperative fasting periods lead to catabolic states and decelerate recovery after surgery. Valid plasma markers reflecting the patients' metabolic state may improve tailored nutrition support before surgery. Within this study, we sought to advance the knowledge on fasting time-sensitive plasma markers that allow the metabolic characterisation of surgical patients for an optimised preoperative metabolic preparation.

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Dynamic liver function assessment by the [C]methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic cytochrome -450 (CYP) 1A2 activity. One proven strategy for preoperative risk assessment in liver surgery includes the combined assessment of the dynamic liver function by the LiMAx test, the volumetric analysis of the liver, and calculation of future liver remnant function. This so-called volume-function analysis assumes that the remaining CYP1A2 activity in any tumor lesion is zero.

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Immunofluorescence (IF) staining of paraffin-embedded tissues is a frequently used method to answer research questions or even detect the abundance of a certain protein for diagnostic use. However, the signal originating from specific antibody-staining might be distorted by autofluorescence (AF) of the assessed tissue. Although the AF phenomenon is well known, its presence is often neglected by insufficient staining controls.

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