Publications by authors named "Jonas Sommer"
Unlabelled: Uveal melanoma is a rare form of melanoma that originates in the eye, exerts widespread therapeutic resistance, and displays an inherent propensity for hepatic metastases. Because metastatic disease is characterized by poor survival, there is an unmet clinical need to identify new therapeutic targets in uveal melanoma. Here, we show that the pleiotropic cytokine midkine is expressed in uveal melanoma.
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- Uveal melanoma is the most common eye cancer in adults, and while treatments for the primary tumor have improved, they fail to prevent metastasis or enhance survival.
- Researchers are investigating immunotherapy using MHC II uveal melanoma cell-based vaccines to stimulate CD4+ T cells that can attack the tumor.
- The study found that these vaccines effectively activated various CD4+ T cell types, leading to a strong immune response without being suppressed by regulatory T cells, showcasing their potential as a new treatment option for patients with uveal melanoma.