Publications by authors named "Jonas Setzke"

Article Synopsis
  • Fluorescence microscopy has been a key technique in biological sciences, but traditional methods are often limited to a few targets using primary and fluorescently conjugated secondary antibodies.
  • New super-resolution techniques like Exchange-PAINT and SUM-PAINT allow for higher multiplexing but require specialized equipment and expertise.
  • The newly developed NanoPlex method improves multiplexing accessibility by using engineered secondary nanobodies to selectively remove fluorescence signals, allowing for the analysis of up to 21 targets in 3D confocal imaging and 5-8 targets in advanced super-resolution techniques.
View Article and Find Full Text PDF

Purpose: SLC4A10 encodes a plasma membrane-bound transporter, which mediates Na-dependent HCO import, thus mediating net acid extrusion. Slc4a10 knockout mice show collapsed brain ventricles, an increased seizure threshold, mild behavioral abnormalities, impaired vision, and deafness.

Methods: Utilizing exome/genome sequencing in families with undiagnosed neurodevelopmental disorders and international data sharing, 11 patients from 6 independent families with biallelic variants in SLC4A10 were identified.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: