Histologic Characterization of Tumor-Adjacent Mammary Adipose Tissue in Normal-Weight and Overweight/Obese Patients with Triple-Negative Breast Cancer.

Obesity is a risk factor of several types of cancer, including breast cancer. In this study, we aimed to histologically characterize the adipose tissue of the tumor microenvironment (TME) of triple-negative breast cancer (TNBC) in overweight/obese versus normal-weight patients. TNBC tissue sections from normal-weight (BMI) and overweight/obese patients (BMI) were stained with antibodies against CD68, CD163, CD31, CD34, and vimentin.

Concept and development of a telemedical supervision system for anesthesiology in operating rooms using the interoperable communication standard ISO/IEEE 11073 SDC.

Objectives: Discussion of a telemedical supervision system for anesthesiology in the operating room using the interoperable communication protocol SDC. Validation of a first conceptual demonstrator and highlight of strengths and weaknesses.

Methods: The system includes relevant medical devices, a central anesthesia workstation (AN-WS), and a remote supervision workstation (SV-WS) and the concept uses the interoperability standard ISO/IEEE 11073 SDC.

E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.

S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation occurs in an NLRP3 inflammasome-dependent fashion.

Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation .

Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation. Under various pathological conditions, pUMOD accumulates within the tubular lumen and reaches extratubular sites where it may interact with renal interstitial cells.