Publications by authors named "Jonas O Fisch"
Article Synopsis
- The lateral superior olive (LSO) is a part of the brain that helps us locate sounds by looking at the different loudness levels in each ear.
- Scientists studied young mice to learn about the different types of neurons (tiny brain cells) in the LSO and found two main groups: ones that help you sense sounds (pLSOs) and others that protect your ears from loud noises (LOCs).
- They discovered many important genes that make these neurons work, some of which are new to their research, helping us understand how these neurons develop and function in hearing.
Sound localization involves information analysis in the lateral superior olive (LSO), a conspicuous nucleus in the mammalian auditory brainstem. LSO neurons weigh interaural level differences (ILDs) through precise integration of glutamatergic excitation from the cochlear nucleus (CN) and glycinergic inhibition from the medial nucleus of the trapezoid body (MNTB). Sound sources can be localized even during sustained perception, an accomplishment that requires robust neurotransmission.
View Article and Find Full Text PDFKey Points: The lateral superior olive (LSO), a brainstem hub involved in sound localization, integrates excitatory and inhibitory inputs from the ipsilateral and the contralateral ear, respectively. In gerbils and rats, inhibition to the LSO reportedly shifts from GABAergic to glycinergic within the first three postnatal weeks. Surprisingly, we found no evidence for synaptic GABA signalling during this time window in mouse LSO principal neurons.
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