S1PR deficiency results in reduced germinal center formation but only marginally affects antibody production.

Introduction: Splenic B cells exhibit a high expression of the G protein-coupled sphingosine-1-phosphate (S1P) receptor type 4 (S1PR). Little is known about the functional relevance of S1PR expression on those cells.

Methods: In this study, S1PR-deficient mice were used to study the role of S1PR-mediated S1P signaling in B cell motility and for the maintenance of the splenic architecture under steady state conditions as well as in polymicrobial abdominal sepsis .

Cell cycle-related genes associate with sensitivity to hydrogen peroxide-induced toxicity.

Reactive oxygen species (ROS) such as hydrogen peroxide (HO) are well-described agents in physiology and pathology. Chronic inflammation causes incessant HO generation associated with disease occurrences such as diabetes, autoimmunity, and cancer. In cancer, conditioning of the tumor microenvironment, e.

Increased mortality and altered local immune response in secondary peritonitis after previous visceral operations in mice.

Postoperative peritonitis is characterized by a more severe clinical course than other forms of secondary peritonitis. The pathophysiological mechanisms behind this phenomenon are incompletely understood. This study used an innovative model to investigate these mechanisms, combining the models of murine Colon Ascendens Stent Peritonitis (CASP) and Surgically induced Immune Dysfunction (SID).

Tumor cell metabolism correlates with resistance to gas plasma treatment: The evaluation of three dogmas.

Gas plasma is a partially ionized gas increasingly recognized for targeting cancer. Several hypotheses attempt to explain the link between plasma treatment and cytotoxicity in cancer cells, all focusing on cellular membranes that are the first to be exposed to plasma-generated reactive oxygen species (ROS). One proposes high levels of aquaporins, membrane transporters of water and hydrogen peroxide, to mark tumor cell line sensitivity to plasma treatment.