Publications by authors named "Jonas Marx"
Restoring ischaemic myocardial tissue perfusion is crucial for minimizing infarct size. Acute mechanical left ventricular (LV) support has been suggested to improve infarct tissue perfusion. However, its regulatory mechanism remains unclear.
View Article and Find Full Text PDFObjective: Isolated tricuspid valve surgery is perceived as high-risk. This perception is nurtured by patients who often present with substantial liver dysfunction, which is inappropriately reflected in current surgical risk scores (eg, the Society of Thoracic Surgeons [STS] score has no specific tricuspid model). The Model for End-Stage Liver Disease (MELD) has was developed as a measure for the severity of liver dysfunction.
View Article and Find Full Text PDFArticle Synopsis
- Both glucose and lactate are crucial for heart metabolism, especially under stress, as they get converted to pyruvate for energy production in mitochondria.
- The study found that mice lacking a key protein for pyruvate transport (MPC1) developed severe heart issues, leading to pathological changes and early death.
- A ketogenic or high-fat diet helped reverse damage in these mice by providing alternative energy sources, but only a preemptive diet was effective in saving them from rapid heart failure after an induced stress condition.