Publications by authors named "Jonas Martin"
Int J Mol Sci
October 2024
Article Synopsis
- The BAFF-APRIL system is important in systemic lupus erythematosus (SLE) as it helps B cells survive and contribute to autoimmunity; this study examined BCMA expression in B cell subsets in SLE patients and healthy controls.
- SLE patients showed higher BCMA expression on B cells compared to healthy controls, with notable increases in memory B cells and a correlation between BCMA levels and disease markers like anti-dsDNA antibodies.
- Belimumab treatment reduced BCMA expression and other components of the BAFF-APRIL system, indicating its potential as both a treatment strategy and a biomarker for monitoring disease activity in SLE.
