Impact of arrhythmogenic calmodulin variants on small conductance Ca -activated K (SK3) channels.

Calmodulin (CaM) is a ubiquitous Ca -sensing protein regulating many important cellular processes. Several CaM-associated variants have been identified in a small group of patients with cardiac arrhythmias. The mechanism remains largely unknown, even though a number of ion channels, including the ryanodine receptors and the L-type calcium channels have been shown to be functionally affected by the presence of mutant CaM.