Equivalent user experience and improved community augmented meta-analyses knowledge for a new version of a Plain Language Summary guideline.

Plain Language Summaries (PLS) offer a promising solution to make meta-analytic psychological research more accessible for non-experts and laypeople. However, existing writing guidelines for this type of publication are seldom grounded in empirical studies. To address this and to test two versions of a new PLS guideline, we investigated the impact of PLSs of psychological meta-analyses on laypeoples' PLS-related knowledge and their user experience (accessibility, understanding, empowerment).

Exploring knowledge and implementation gaps of activity-based therapy in centers lacking specialized spinal cord injury services: understanding therapists' perspectives.

Study Design: Qualitative exploratory OBJECTIVES: Rehabilitation following spinal cord injury (SCI) is a life-long process involving healthcare in a variety of settings, including facilities lacking SCI-specific services (i.e., non-SCI-specialized centers).

Indicators of trustworthiness in lay-friendly research summaries: Scientificness surpasses easiness.

Lay readers' trust in scientific texts can be shaped by perceived text easiness and scientificness. The two effects seem vital in a time of rapid science information sharing, yet have so far only been examined separately. A preregistered online study was conducted to assess them jointly, to probe for author and text trustworthiness overlap, and to investigate interindividual influences on the effects.

To Have the Best Interest at Heart: Analyzing the Match Between Laypersons' Interests and Publication Activity in Psychology.

There is a growing public interest in science and, by extension, in psychology, and human behavior. Yet, detailed investigations on whether academic psychological research activity matches lay interests are still scarce. In addition, while lay-friendly communication of research findings becomes continually more important, it is unclear which subfields of psychological research are particularly interesting to laypeople.

How to Put It Plainly? Findings From Two Randomized Controlled Studies on Writing Plain Language Summaries for Psychological Meta-Analyses.

Plain language summaries (PLS) aim to communicate research findings to laypersons in an easily understandable manner. Despite the societal relevance of making psychological research findings available to the public, our empirical knowledge on how to write PLS of psychology studies is still scarce. In this article, we present two experimental studies investigating six characteristics of PLS for psychological meta-analyses.

Patterns of univariate and multivariate plasticity to elevated carbon dioxide in six European populations of .

The impact of elevated carbon dioxide on plants is a growing concern in evolutionary ecology and global change biology. Characterizing patterns of phenotypic integration and multivariate plasticity to elevated carbon dioxide can provide insights into ecological and evolutionary dynamics in future human-altered environments. Here, we examined univariate and multivariate responses to carbon enrichment in six functional traits among six European accessions of .

Induced mutations alter patterns of quantitative variation, phenotypic integration, and plasticity to elevated CO in Arabidopsis thaliana.

A key step toward predicting responses to climate change is characterizing genetic variation in populations. While short-term responses will likely be shaped by currently available genetic variation, longer-term evolutionary responses will depend on the supply of novel variation by, ultimately, mutation. Studying mutational contributions to phenotypic variation can provide insights into the extent of potential variation on which selection may operate in future human-altered environments.

Hawaiian Drosophila genomes: size variation and evolutionary expansions.

This paper reports genome sizes of one Hawaiian Scaptomyza and 16 endemic Hawaiian Drosophila species that include five members of the antopocerus species group, one member of the modified mouthpart group, and ten members of the picture wing clade. Genome size expansions have occurred independently multiple times among Hawaiian Drosophila lineages, and have resulted in an over 2.3-fold range of genome sizes among species, with the largest observed in Drosophila cyrtoloma (1C = 0.

Two-dimensional separation of ionic species by hyphenation of capillary ion chromatography × capillary electrophoresis-mass spectrometry.

The separation of complex mixtures such as biological or environmental samples requires high peak capacities, which cannot be established with a single separation technique. Therefore, multidimensional systems are in demand. In this work, we present the hyphenation of the two most important (orthogonal) techniques in ion analysis, namely, ion chromatography (IC) and capillary electrophoresis (CE), in combination with mass spectrometry.

Very fast capillary electrophoresis with electrochemical detection for high-throughput analysis using short, vertically aligned capillaries.

A method for conducting fast and efficient capillary electrophoresis (CE) based on short separation capillaries in vertical alignment was developed. The strategy enables for high-throughput analysis from small sample vials (low microliter to nanoliter range). The system consists of a lab-made miniaturized autosampling unit and an amperometric end-column detection (AD) cell.

Lack of Clostridium difficile infection in patients treated with rifaximin for hepatic encephalopathy: a retrospective analysis.

Goals: The purpose of this study was to assess the incidence of Clostridium difficile infection in patients who received rifaximin for the treatment of hepatic encephalopathy (HE).

Methods: Medical charts of patients who received rifaximin for the treatment of HE were reviewed. The number of patients who developed diarrhea during treatment with rifaximin and results of latex agglutination assays to detect C.

Electrochemical methods in conjunction with capillary and microchip electrophoresis.

Electromigrative techniques such as capillary and microchip electrophoresis (CE and MCE) are inherently associated with various electrochemical phenomena. The electrolytic processes occurring in the buffer reservoirs have to be considered for a proper design of miniaturized electrophoretic systems and a suitable selection of buffer composition. In addition, the control of the electroosmotic flow plays a crucial role for the optimization of CE/MCE separations.

Durability of rifaximin response in hepatic encephalopathy.

Goals: To evaluate the durability of the response to rifaximin for treatment of hepatic encephalopathy (HE).

Background: The nonsystemic antibiotic rifaximin has been approved for maintenance of HE remission, and several studies have indicated the efficacy of rifaximin for acute HE; however, the duration of therapeutic response for >6 months remains unknown.

Study: Medical records of patients with cirrhosis who received rifaximin maintenance therapy for HE between January 2004 and May 2009 were reviewed.

Comparison of the performance characteristics of two tubular contactless conductivity detectors with different dimensions and application in conjunction with HPLC.

Two tubular capacitively coupled contactless conductivity detection (C(4)D) cells with different geometric dimensions were evaluated with regard to their main analytical characteristics under non-separation and separation conditions in conjunction with liquid chromatography. A comparison of the performance of the tubular cells to a previously tested thin-layer detection cell was drawn. Additionally, using a theoretical model the experimental results were compared with sets of calculated values and partially enabled to model the complex behavior of C(4)D detection in combination with high-performance liquid chromatography (HPLC).

Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection.

Background & Aims: Farglitazar (GI262570), an insulin-sensitizing agent, selectively binds and activates peroxisome proliferator-activated receptor gamma (PPARgamma) and inhibits stellate cell activation. We evaluated its antifibrotic effect in patients with chronic hepatitis C that did not respond to standard-of-care therapy.

Methods: Patients with fibrosis of Ishak stages 2-4 (n = 265), based on analysis of liver biopsy samples, were randomly assigned to groups given once-daily doses of 0.

Adult onset urea cycle disorder in a patient with presumed hepatic encephalopathy.

Deficiency of any of the 5 enzymes in the urea cycle results in the accumulation of ammonia, leading to encephalopathy; which if untreated, can be lethal and produce devastating neurologic sequelae in long-term survivors. We hereby present an interesting case that presented with hyperammonemia and encephalopathy; later found to have an urea cycle defect.