Publications by authors named "Jonas Ludvigsson"
Article Synopsis
- The study aimed to uncover the molecular pathways linking type 2 diabetes (T2D) with gastrointestinal (GI) diseases using a two-stage Mendelian randomisation approach.
- Researchers utilized genetic data to evaluate the associations between T2D and various proteins, finding significant links between specific proteins and GI diseases such as cholelithiasis and cirrhosis.
- The findings highlight that certain proteins, particularly SULT2A1 and ADH1B, may mediate the relationship between T2D and GI diseases, offering new biological insights into these conditions.
Article Synopsis
- - The study aimed to investigate the risk of pancreatic cancer following benign gallbladder disease (GBD) in a nationwide cohort of Swedish individuals aged 20-79 who had undergone cholecystitis or cholecystectomy from 1992 to 2016, along with matched non-exposed individuals.
- - Over a 15-year period, the researchers found that those with a history of GBD had a significantly higher incidence of pancreatic cancer within the first two years after diagnosis, with a hazard ratio of 2.74, particularly in younger patients aged 20-49, where the risk was even more pronounced.
- - The results suggest the need for increased clinical monitoring for pancreatic cancer in patients who have
Article Synopsis
- - Celiac disease (CeD) is being diagnosed more frequently in older adults, but research on complications in this age group is limited, prompting an investigation into frailty among older CeD patients.
- - A study involving over 4,600 older adults with CeD and nearly 22,000 controls showed that CeD patients had a significantly higher prevalence of frailty at baseline (54.4% vs. 29.7%), and those without baseline frailty had a 66% increased risk of becoming frail within 5 years compared to controls.
- - The findings indicate that older adults with CeD are more vulnerable to frailty, and even successful treatment such as mucosal healing does not reduce the risk
Risk of Cancer Diagnosis in Patients With Eosinophilic Esophagitis Using a Nationwide Swedish Population Cohort.
United European Gastroenterol J
December 2024
Article Synopsis
- Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus that may be linked to cancer, prompting a study to explore this association.
- A cohort study in Sweden analyzed 1,580 EoE patients and matched them with 7,533 reference individuals, tracking cancer development over a median of 7 years.
- While no overall cancer risk was found in EoE patients, there was a significant increase in the risk of esophageal cancer and Barrett's esophagus, though these cases were very rare, warranting caution in interpreting the results.
Background & Aims: Oxidative stress is an essential factor in the pathogenesis of inflammatory bowel disease (IBD). A previous study found protective potential of some antioxidative nutrients against IBD. However, the association between total antioxidant capacity (TAC) of the diet and incident IBD is unclear.
View Article and Find Full Text PDFBackground: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a risk factor for cardiovascular disease. However, whether family members of individuals with MASLD also share an increased cardiovascular risk is unknown.
Methods: We created a nationwide multigenerational cohort study identifying all family members of Swedish adults diagnosed with biopsy-proven MASLD (1969-2017) and of matched general population comparators (by age, sex, calendar year, and county of residence).
Background: Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.
Aims: To determine the fracture risk in IBD during periods with and without histological inflammation.
Background: Co-occurrence of inflammatory bowel disease (IBD) and type 1 diabetes (T1D) has been linked to poor clinical outcomes, but evidence on their bidirectional associations remain scarce. This study aims to investigate their bidirectional associations.
Methods: A nationwide matched cohort and case-control study with IBD patients identified between 1987 and 2017.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally, increasingly affecting obese young individuals.
- This study aimed to evaluate how perinatal factors like birth weight and gestational age influence the risk of developing MASLD and its progressions, using data from Sweden.
- Results indicated that low birth weight significantly increases the likelihood of developing MASLD in young individuals, whereas high birth weight did not show a similar risk increase compared to normal birth weight.
Diverticular disease and risk of incident major adverse cardiovascular events: A nationwide matched cohort study.
Eur Heart J Qual Care Clin Outcomes
August 2024
Background: An increased risk of cardiovascular disease (CVD) has been reported in patients with diverticular disease (DD). However, there are knowledge gaps about specific risks of each major adverse cardiovascular event (MACE) component.
Methods: This nationwide cohort study included Swedish adults with DD (1987-2017, N=52,468) without previous CVD.
Rare and severe adverse events in children with inflammatory bowel disease.
Lancet Child Adolesc Health
September 2024
Introduction: Microscopic colitis (MC) is an inflammatory condition of the large intestine. Primarily diagnosed in middle-aged and older adults, the incidence of the disease has increased markedly during the past few decades. While MC is associated with a reduced quality of life, large-scale studies on the association with future psychiatric disorders are lacking.
View Article and Find Full Text PDFIntroduction: We aimed to assess the risk of serious infection in patients with inflammatory bowel disease (IBD) treated with vedolizumab compared with those treated with anti-tumor necrosis factors (TNF) and the general population.
Methods: In this Swedish cohort study, treatment episodes were identified from nationwide health registers. We used Cox regression with propensity score-matched cohorts to estimate hazard ratios (HRs) for incident serious infections, defined as infections requiring hospital admission.
Background: Microscopic colitis (MC) is an inflammatory disorder of the colon. To date, the relationship between inflammatory eye diseases and MC is unclear.
Objective: To assess whether inflammatory eye disease (iridocyclitis and episcleritis) is a risk factor for MC.
Background: Inflammatory diseases have been associated with an increased cardiovascular risk. However, data on incident major adverse cardiovascular events (MACE) from large population-based cohorts of patients with eosinophilic esophagitis (EoE) is lacking.
Methods: This study included all Swedish adults with EoE without a record of previous cardiovascular disease (CVD) (1990-2017, N = 1546) with follow-up until 2019.
Background: Celiac disease (CeD) is associated with several immune-mediated disorders, but it is unclear whether it is associated with eosinophilic esophagitis (EoE).
Objective: We sought to examine the risk of EoE in patients with biopsy-verified CeD compared with matched controls and siblings.
Methods: Using nationwide population-based histopathology data, we identified 27,338 patients with CeD diagnosed in the period 2002 to 2017 in Sweden.
Background & Aims: Inflammatory bowel disease (IBD) is frequently accompanied by kidney complications. Potential triggers or subpopulations at high-risk of kidney problems are not well-elucidated. We hypothesized that surgical interventions, specifically colectomy, might in part explain this risk.
View Article and Find Full Text PDFIntroduction: Despite its increasing prevalence, the economic impact of eosinophilic esophagitis (EoE) is understudied.
Methods: We estimated the societal economic burden of EoE by using real-world data from Swedish health registers.
Results: Patients with EoE had 45% higher societal cost ($6,290 vs $4,349) compared with the general population, primarily driven by increased healthcare costs ($2,414 vs $1,022), which accounted for 72% of the excess societal cost in EoE.
Aims/hypothesis: While the association between coeliac disease and type 1 diabetes is well documented, the association of coeliac disease with type 2 diabetes risk remains undetermined. We conducted a nationwide cohort and Mendelian randomisation analysis to investigate this link.
Methods: This nationwide matched cohort used data from the Swedish ESPRESSO cohort including 46,150 individuals with coeliac disease and 219,763 matched individuals in the comparator group selected from the general population, followed up from 1969 to 2021.
Background And Aims: Dysregulation of inflammatory and immune responses has been implicated in the pathogenesis of heart failure (HF). But even if inflammation is a prerequisite for inflammatory bowel disease (IBD), little is known about HF risk in IBD.
Methods: In this Swedish nationwide cohort, patients with biopsy-confirmed IBD were identified between 1969 and 2017 [n = 81 749, Crohn's disease (CD, n = 24 303), ulcerative colitis (UC, n = 45 709), and IBD-unclassified (IBD-U, n = 11 737)].