Publications by authors named "Jonas Engelbertz"
Cyclophosphamide pulse therapy as treatment for severe interstitial lung diseases.
Sarcoidosis Vasc Diffuse Lung Dis
July 2020
Introduction: Besides invasive or non-invasive ventilation, treatment of severe forms of interstitial lung diseases (ILD) includes immunosuppressive medication. In case of refractory organ- or life-threatening courses of disease, cyclophosphamide pulse therapy can serve as a rescue treatment option.
Objectives: To investigate therapeutic and prognostic effects of cyclophosphamide for the treatment of severe forms of ILD on intensive care unit (ICU) we performed this analysis.
Ethnopharmacological Relevance: Extracts from Thymus vulgaris L. and Thymus zygis L. are traditionally used for bronchitis, catarrhs of the respiratory tract and supportive treatment of pertussis.
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- Thyme has broncholytic and secretomotoric effects attributed mainly to its components thymol and carvacrol, which interact with beta (2) receptors.
- Both thymol and carvacrol show a concentration-dependent antispasmodic effect in the trachea and increased mucociliary transport in experiments with rats and mice.
- Extracts with normal thymol levels outperform those with very low levels in terms of effectiveness for relaxation and antispasmodic action, while still demonstrating activity even when thymol concentrations are minimal.
Thyme extract is known to posses spasmolytic effects on isolated trachea and to increase ciliary activity. A small part of this effect is mediated via beta (2) receptors, but other receptors are supposed to be involved. Endothelin has a pathophysiological impact in asthma with respect to hyper-reagibility and contracting isolated trachea smooth muscles and was, therefore, investigated.
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