Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells.

The involvement of peroxisomes in cellular hydrogen peroxide (HO) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965. While the role of HO substantially changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these signaling events is still largely underappreciated. This is mainly because the number of known protein targets of peroxisome-derived HO is rather limited and testing of specific targets is predominantly based on knowledge previously gathered in related fields of research.