Publications by authors named "Jonas Altendorf"
Nat Biotechnol
October 2024
Article Synopsis
- Fluorescence microscopy has advanced to subnanometer resolution but struggles to visualize single proteins or small complexes; researchers have developed a method called ONE microscopy to address this.
- ONE microscopy expands specimens, tags them with fluorophores, and captures videos to analyze fluorescence fluctuations, allowing for the visualization of individual proteins' shapes at around 1-nm resolution.
- This technique can observe protein conformational changes and has potential applications in clinical settings, such as analyzing protein aggregates in cerebrospinal fluid from Parkinson's patients, bridging high-resolution biology and light microscopy for new discoveries.
