The 5-HT receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons.

Morphological remodeling of dendritic spines is critically involved in memory formation and depends on adhesion molecules. Serotonin receptors are also implicated in this remodeling, though the underlying mechanisms remain enigmatic. Here, we uncovered a signaling pathway involving the adhesion molecule L1CAM (L1) and serotonin receptor 5-HT (5-HTR, encoded by ).