Publications by authors named "Jonah Popp"
Objective: To meta-analyze clinical efficacy and safety of ketamine compared with other anesthetic agents in the course of electroconvulsive therapy (ECT) in major depressive episode (MDE).
Methods: PubMed/MEDLINE, Cochrane Library, Embase, GoogleScholar, and US and European trial registries were searched from inception through May 23, 2023, with no language limits. We included RCTs with (1) a diagnosis of MDE; (2) ECT intervention with ketamine and/or other anesthetic agents; and (3) measures included: depressive symptoms, cognitive performance, remission or response rates, and serious adverse events.
Objective: To meta-analyze clinical efficacy and safety of ketamine compared with other anesthetic agents in the course of electroconvulsive therapy (ECT) in major depressive episode (MDE).
Methods: PubMed/MEDLINE, Cochrane Library, Embase, GoogleScholar, and US and European trial registries were searched from inception through May 23, 2023, with no language limits. We included RCTs with (1) a diagnosis of MDE; (2) ECT intervention with ketamine and/or other anesthetic agents; and (3) measures included: depressive symptoms, cognitive performance, remission or response rates, and serious adverse events.
Article Synopsis
- The FACS, GILDA, and COLOFOL trials have raised questions about the effectiveness of intensive extracolonic surveillance and metastasectomy in nonmetastatic colorectal cancer, suggesting the need to reconsider these conclusions based on statistical power.
- A microsimulation model was used to analyze the trials, revealing that predicted mortality reductions were low (≤5%) and statistical power was insufficient (<10%) to detect significant benefits, which may contribute to misleading survival rates reported in the trials.
- After adjustments and further analysis, the model indicated possible small increases in life expectancy with more intensive surveillance, advocating for further, adequately powered trials before dismissing the potential benefits of metastasectomy and extracolonic surveillance.
Objective: To determine the willingness-to-pay (WTP) of family caregivers to learn care strategies for persons living with dementia (PLwD).
Design: Randomized clinical trial.
Setting: Community-dwelling PLwD and their caregivers (dyads) in Maryland and Washington, DC.
Cost-effectiveness of surveillance with CT colonography after resection of colorectal cancer.
BMJ Open Gastroenterol
September 2020
Objective: Surveillance following colorectal cancer (CRC) resection uses optical colonoscopy (OC) to detect intraluminal disease and CT to detect extracolonic recurrence. CT colonography (CTC) might be an efficient use of resources in this situation because it allows for intraluminal and extraluminal evaluations with one test.
Design: We developed a simulation model to compare lifetime costs and benefits for a cohort of patients with resected CRC.
As part of a clinical trial comparing the utility of computed tomographic colonography (CTC) and optical colonoscopy (OC) for post colorectal cancer resection surveillance, we explored the diagnostic yield and costs of a strategy of CTC followed by OC if a polyp is observed (abbreviated CTC_S), versus OC 1 year following curative bowel resection, using the detection of actionable polyps on OC as the criterion. Using data from 231 patients who underwent same-day CTC followed by OC, we created a decision tree that outlined the choices and outcomes at 1-year clinical follow-up. Colorectal polyp prevalence, sensitivity, and specificity of CTC were compared with five exemplary studies and meta-analyses.
View Article and Find Full Text PDFObjectives: We conducted a cost-effectiveness analysis and model-based cost-utility and cost-benefit analysis of increased dosage (3 vs. 1 consecutive contests) and enhanced content (supplemental smoking-cessation counseling) of the Quit-and-Win contest using data from a randomized control trial enrolling college students in the US.
Methods: For the cost-utility and cost-benefit analyses, we used a microsimulation model of the life course of current and former smokers to translate the distribution of the duration of continuous abstinence among each treatment arm's participants observed at the end of the trial (N = 1217) into expected quality-adjusted life-years (QALYs) and costs and an incremental net monetary benefit (INMB).