Low-Dose Δ9-THC Produces Antinociception in Female, But Not Male Rats.

The analgesic effects of delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, have been widely promoted. Unfortunately, animal research is limited by the use of high doses and pain-evoked tests. Motor and psychoactive effects of THC may suppress evoked responses in the absence of antinociceptive effects.

Comparative benefits of social housing and buprenorphine on wheel running depressed by morphine withdrawal in rats.

Rationale: Social support and opioid replacement therapy are commonly used to treat opioid withdrawal.

Objective: The present study tested the hypothesis that social housing and buprenorphine administration can restore wheel running depressed by morphine withdrawal in rats.

Results: Experiment 1 assessed disruptive side effects of buprenorphine and found that administration of low doses (3.

Social housing promotes recovery of wheel running depressed by inflammatory pain and morphine withdrawal in male rats.

The increased use of opioids to treat pain has led to a dramatic increase in opioid abuse. Our previous data indicate that pain may facilitate the development of opioid abuse by increasing the magnitude and duration of opioid withdrawal. The present study tested the hypothesis that social housing would facilitate recovery of activity depressed by pain and opioid withdrawal.