FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis.

Neutrophils are the most abundant inflammatory cells at the earliest stages of wound healing and play important roles in wound repair and fibrosis. Formyl peptide receptor 1 (FPR-1) is abundantly expressed on neutrophils and has been shown to regulate their function, yet the importance of FPR-1 in fibrosis remains ill defined. FPR-1-deficient (fpr1-/-) mice were protected from bleomycin-induced pulmonary fibrosis but developed renal and hepatic fibrosis normally.

Hapten Synthesis, Antibody Development, and a Highly Sensitive Indirect Competitive Chemiluminescent Enzyme Immunoassay for Detection of Dicamba.

Although dicamba has long been one of the most widely used selective herbicides, some U.S. states have banned the sale and use of dicamba because of farmers complaints of drift and damage to nonresistant crops.

What are junior doctors for? The work of Foundation doctors in the UK: a mixed methods study.

Objectives: To examine what activities constitute the work of Foundation doctors and understand the factors that determine how that work is constructed.

Design: Cross-sectional mixed methods study. Questionnaire survey of the frequency with which activities specified in curricular documents are performed.

Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.

Rationale: Aspiration of infective subglottic secretions causes ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Mechanisms underlying subglottic colonization in critical illness have not been defined, limiting strategies for targeted prevention of VAP.

Objectives: To characterize subglottic host defense dysfunction in mechanically ventilated patients in the ICU; to determine whether subglottic mucin contributes to neutrophil phagocytic impairment and bacterial growth.

The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction.

The nucleolus is a multifunctional structure within the nucleus of eukaryotic cells and is the primary site of ribosome biogenesis. Almost all viruses target and disrupt the nucleolus--a feature exclusive to this pathogen group. Here, using a combination of bio-imaging, genetic and biochemical analyses, we demonstrate that the enteropathogenic E.

The locust jump: an integrated laboratory investigation.

The locust is well known for its ability to jump large distances to avoid predation. This class sets out a series of investigations into the mechanisms underlying the jump enabling students to bring together information from biomechanics, muscle physiology, and anatomy. The nature of the investigation allows it to be undertaken at a number of levels of complexity from relatively simple comparative observations to detailed analysis of the properties of the muscles and the energy storage systems involved in powering the jump.

Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke.

Background: diabetes mellitus not only increases the risk of ischaemic stroke two- to four-fold but also adversely inXuences prognosis. The prevalence of recognised diabetes mellitus in acute stroke patients is between 8 and 20%, but between 6 and 42% of patients may have undiagnosed diabetes mellitus before presentation. Post-stroke hyperglycaemia is frequent and of limited diagnostic value and the oral glucose tolerance test assumes that the patient is clinically stable and eating normally.

Tremor in the human hand following peripheral nerve transection and reinnervation.

Slow movements and position holding by the digits are both characterised by 8-10 Hz tremor which appears to be centrally generated. Denervation and subsequent reinnervation lead to significant alterations in peripheral connectivity and reflex organisation. We have tested the hypothesis that 8-10 Hz tremor is present in the digits of subjects following a complete nerve lesion.