Effects of partial lidocaine inactivation of the paramedian pontine reticular formation on saccades of macaques.

To investigate the brain stem control of saccadic eye movements, the paramedian pontine reticular formation (PPRF) in rhesus monkeys was temporarily and partially inactivated with the local anesthetic lidocaine. The influence on ipsilesional, contralesional, and upward saccades was examined. While the effects of the inactivation on contralesional and upward saccades were inconsistent and small, consistent and marked modifications were observed for ipsilesional movements.