Jon McCormack: Art Infused With [Artificial] Intelligence.

We requested an interview with Jon McCormack after we encountered his work when looking for artists doing compelling work at the intersection of art and artificial intelligence (AI).

The safety profile and effectiveness of propofol-remifentanil mixtures for total intravenous anesthesia in children.

Background: Total intravenous anesthesia is used in less than 10% of operations in the UK. Many pediatric anesthetists in the UK and Ireland administer total intravenous anesthesia to children using a mixture of propofol and remifentanil in the same syringe. This unlicensed drug has not been studied clinically, because of lack of Medicines and Healthcare products Regulatory Agency (UK) or Food and Drug Administration (US) approval to undertake such studies.

Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis.

Rationale: The pathogenesis of respiratory syncytial virus (RSV) bronchiolitis in infants remains poorly understood. Mouse models implicate pulmonary T cells in the development of RSV disease. T cell responses are initiated by dendritic cells (DCs), which accumulate in lungs of RSV-infected mice.

Paediatric workload of an adult retrieval service in Scotland.

The Emergency Medical Retrieval Service (EMRS) provides adults with life-threatening conditions in remote areas with timely interventions and rapid access to definitive medical care, including a primary response service. Paediatric patients are managed under a separate network. Despite this, there has been an increase in paediatric retrievals by EMRS.

The presumed central nervous system effects of rocuronium in a neonate and its reversal with sugammadex.

We describe a 2-day-old male infant who received rocuronium as part of general anesthesia for a tracheal esophageal fistula repair. Postoperatively, he had prolonged central and peripheral neuromuscular blockade despite cessation of the rocuronium infusion several hours previously. This case discusses the presumed central nervous system effects of rocuronium in a neonate and its effective reversal with sugammadex.

Fatal and near-fatal grape aspiration in children.

Choking remains an important cause of morbidity and mortality in young children. Whole seedless grapes are a popular fruit snack to give to young children.We present 3 cases of grape aspiration, discussing the emergency care from basic life support to specialist treatment.

Slower administration of propofol preserves adequate respiration in children.

Background: Propofol is a versatile anesthetic agent used in pediatric practice to facilitate investigational and interventional procedures. Propofol can cause significant respiratory depression, the management of which may require advanced airway management skills. This investigation aimed to increase the safety of propofol administration by developing a dosing schedule that would preserve spontaneous respiration in at least 95% of subjects.

The effect of age on the dose of remifentanil for tracheal intubation in infants and children.

Introduction: This study aimed to determine the age-specific bolus dose of remifentanil (ED(50)) to facilitate tracheal intubation without the use of neuromuscular blocking agents.

Methods: ASA 1-2 subjects were recruited into three groups of 0-3 months (group I), 4-12 months (group II), and 1-3 years (group III) of age. A sequential up-and-down design determined the remifentanil bolus dose, which was initially started at 3 mcg x kg(-1) and adjusted in 1 mcg x kg(-1) increments (range 1-6 mcg x kg(-1)).

The effect of a target controlled infusion of propofol on predictability of recovery from anesthesia in children.

Background: Emergence following termination of a general anesthetic depends on the effect site concentration (C(e)) of the drug declining to an awakening value (C(e)-awake). C(e)-awake has been described in adults, but is unknown in children.

Objectives: To determine C(e)-awake in children following a target-controlled infusion (TCI) of propofol and to assess a C(e)-driven TCI system's ability to predict times to emergence from anesthesia.

Target controlled infusion for kids: trials and simulations.

Target controlled infusion (TCI) for Kids is a computer controlled system designed to administer propofol for general anesthesia. A controller establishes infusion rates required to achieve a specified concentration at the drug's effect site (C(e)) by implementing a continuously updated pharmacokinetic-pharmacodymanic model. This manuscript provides an overview of the system's design, preclinical tests, and a clinical pilot study.

Advances in patient-controlled analgesia: the role of fentanyl ITS.

Effective pain relief is an essential component of a patient's peri-operative care package. Good analgesia has been shown to reduce the incidence of cardiovascular, respiratory and thrombo-embolic complications following surgery. Satisfactory analgesia facilitates early patient ambulation following surgery, which may reduce in-patient stay.

Postoperative pain management: new, convenient analgesic therapies.

Despite the potential benefits to patient health that can result from effective pain management, survey results continue to indicate that acute postoperative pain remains inadequately managed worldwide. The development of novel analgesics and advanced analgesic delivery techniques has the potential to improve current strategies for postoperative pain management. This article outlines the pharmacological principles and clinical utility of recently developed agents and a novel drug delivery device indicated for the management of moderate-to-severe acute postoperative pain.