CSF testosterone: relationship to aggression, impulsivity, and venturesomeness in adult males with personality disorder.

Objective: Studies of various species suggest that testosterone, assayed in various compartments, is correlated with aggression and possibly related behaviors. The objective of this study was to assess the relationship between cerebrospinal fluid testosterone (CSF TEST) and measures of aggression, impulsivity, and venturesomeness in male personality disordered subjects and test the hypothesis that CSF TEST would correlate directly with each measure in this group.

Methods: Lumbar CSF for morning basal levels of testosterone were obtained from 31 male subjects with personality disorder.