Extract and Active Principal of the Neotropical Vine Gilg. Block Fear Memory Reconsolidation.

Gilg. is a neotropical vine native to Central America, investigated as part of a targeted study of the plant family Marcgraviaceae. Our previous research showed that extract of leaf and small branch extract had anxiolytic effects in animals and acts as an agonist for the GABA receptor at the benzodiazepine binding site.

Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation.

: Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol (CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary components of species, and may modulate fear learning in mammals. The CB1 receptor is widely distributed throughout the cortex and some limbic regions typically associated with fear learning. Humans with posttraumatic disorder (PTSD) have widespread upregulation of CB1 receptor density and reduced availability of endogenous cannabinoid anandamide, suggesting a role for the endocannabinoid system in PTSD.

The PERFORM project: using performing arts to increase engagement and understanding of science.

This commentary describes some of the current challenges for science education in the UK and how an EU educational project (PERFORM) is seeking to use performing arts to engage young people with science, its values and the processes of research.

Determination and mitigation of the uncertainty of neutron diffraction measurements of residual strain in large-grained polycrystalline material.

For large-grained samples it is advantageous to perform pairs of neutron diffraction measurements at the same spatial location but rotated 180° around the geometric centre of the gauge volume as a means of minimizing the scatter coming from the random positioning of grains within the gauge volume.