Publications by authors named "Jon Gibbins"
Article Synopsis
- Elevated cytosolic calcium plays a key role in platelet functions such as shape change, secretion, aggregation, and coagulation, primarily through mobilization from endoplasmic reticulum stores and receptor-operated entry pathways.
- The study utilized a high-throughput assay to measure calcium responses in human platelets under different conditions, revealing a significant increase in calcium entry ratios when activating glycoprotein VI (GPVI) or protease-activated receptors (PAR) along with calcium-ATPase inhibition.
- Results indicate that ORAI1 and Na/Ca exchange are the primary channels responsible for calcium entry in platelets, particularly for GPVI and PAR activation, while other channels like TRPC6 and Piezo1/2 showed little to no impact
