[Liver transplantation in Norway through 25 years].

Background: In Norway, liver transplantation has been the treatment of choice for irreversible acute and chronic liver failure for 25 years. The aim of this article is to present a summary of the results obtained.

Material And Methods: All liver transplants performed in Norway in the period 25.

[The incidence and mortality of ARDS in Icelandic intensive care units 1988-1997].

Objective: A retrospective analysis of the epidemiology and intensive care treatment of ARDS in Iceland during the 10 year period, 1988-1997 with observation of trends within the period.

Material And Methods: All ICU admissions in Iceland 1988-1997 were reviewed according to the American-European consensus conference criteria on ARDS to select patients with the diagnosis of ARDS i.e.

[Should patients with severe sepsis be treated with activated protein C?].

Background: Xigris (recombinant human activated protein C) has recently been introduced as a treatment for severe sepsis following a large multicentre trial (the PROWESS trial).

Material And Methods: Critical review of the original paper, follow-up studies and commentaries, and subgroup analyses from the US Food and Drug Administration.

Results: Changes in trial design after the start of the trial as well as inconsistent results in two phases of the trial make interpretation difficult.