Publications by authors named "Jon Boyum"
Cerebrovascular response to continuous cold perfusion and hypothermic circulatory arrest.
J Thorac Cardiovasc Surg
February 2009
Article Synopsis
- This study investigates how hypothermic circulatory arrest and cold cerebral perfusion affect cerebrovascular resistance and whether these effects are linked to cerebral edema, resistance vessel issues, or changes in the microcirculation.
- In experiments with swine, cold perfusion led to constriction of blood vessels, while hypothermic circulatory arrest caused vessel dilation, with both conditions affecting the endothelial cells differently and altering their ability to regulate blood flow.
- The findings suggest that cold cerebral perfusion increases resistance due to vessel constriction, and both hypothermic conditions may lead to issues in blood flow regulation, potentially contributing to brain injury in the post-operative period.
Objectives: The altered expression of matrix metalloproteinases and their inhibitors influences the formation of atherosclerotic abdominal aortic aneurysms. Their association with thoracic aneurysms is less clear. This study describes the expression of metalloproteinases and their inhibitors in atherosclerotic and nonatherosclerotic thoracic aneurysms, and compares these with age-matched controls.
View Article and Find Full Text PDFObjective: Matrix metalloproteinases are endopeptidases that function in cell matrix turnover. Abnormal matrix metalloproteinase activity has been implicated in the formation of atherosclerotic abdominal aortic aneurysms. Recent studies suggest that abnormal matrix metalloproteinase activity may also be associated with the formation of atherosclerotic and nonatherosclerotic thoracic aortic aneurysms.
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