Publications by authors named "Jon August Stefansson"
Article Synopsis
- MITF is a key regulator in melanocytes and melanoma, with the MITF-M isoform being consistently found in the nucleus.
- Mutational analysis identified specific signals within its structure that enable nuclear localization independent of DNA binding and dimerization.
- Furthermore, dimerization-deficient mutants of MITF-M are less stable in melanoma cells, highlighting the importance of the bHLH-Zip domain in both localization and stability of the protein.