Rapid, green disulphide bond formation in water using the corrin dicyanocobinamide.

Peptide chemists seek rapid methods combined with facile purification when producing disulphide bonds post solid-phase synthesis. Current methods typically require long reaction times of up to two days, can result in side-products from over-oxidation and/or degradation, require organic solvents, and/or require challenging purification. Herein, we describe a rapid, green, and facile oxidation of a series of peptides with up to three disulphide bonds.

Investigations of the Copper Bromide-2,2'-Dipyridyl System: Hydrothermal Synthesis and Structural Characterization of Molecular Cu(3)Br(4)(C(10)H(8)N(2))(2), One-Dimensional CuBr(2)(C(10)H(8)N(2)), and Two-Dimensional [Cu(2)(OH)(2)(C(10)H(8)N(2))(2)][Cu(4)Br(6)].

The hydrothermal reactions of CuBr(2), CuBr, and 2,2'-dipyridyl have resulted in the synthesis of three new compounds. Cu(3)Br(4)(C(10)H(8)N(2))(2) (1) is a molecular phase; CuBr(2)(C(10)H(8)N(2)) (2) is a one-dimensional chain structure; and [Cu(2)(OH)(2)(C(10)H(8)N(2))(2)][Cu(4)Br(6)] (3) crystallizes in a two-dimensional sheet structure. All three compounds were characterized by single-crystal X-ray diffraction.