Optimization of a tensile strength prediction model for compacted ribbons using NIR-HIS analysis.

The tensile strength (TS) of compacted ribbon is a critical quality attribute in the roller compaction process that impacts the quality of the finished product. This study investigated the use of Near Infrared Hyperspectral Imaging Spectroscopy (NIR-HIS) technology for predicting TS of compacted ribbons, considering the effects of surface curvature, different spectral preprocessing methods, and variable selection methods on a predictive model based on Partial Least Squares regression (PLSr). The spectral preprocessing methods evaluated were Mean Centering (MC) and Standard Normal Variate (SNV).

Comparative evaluation of accuracy in near-infrared and Raman spectroscopic determinations of component concentration in packed solid mixtures under various packing densities.

Background: Physical characteristics of packed samples, such as packing density, influence subsequent near-infrared (NIR) and Raman spectral features. This potential decrease in accuracy is a concerning issue in practical applications, such as the analysis of pharmaceutical tablets using vibrational spectroscopy. Thus, we compared the accuracy tolerances of both methods under varying packing densities.

A systematic comparison of four pharmacopoeial methods for measuring powder flowability.

Powder flow is one of the crucial factors affecting several pharmaceutical manufacturing processes. Problems due to insufficient powder flow reduce production process efficiency and cause suboptimum product quality. The U.

Application of co-precipitated glutinous rice starch as a multifunctional excipient in direct compression tablets.

Two key properties of excipients for inclusion in direct compression tablets are flowability and compactibility. Glutinous rice starch (GRS) has poor flowability, which limits its use in direct compression tablets. This study aimed to create a multifunctional direct compression excipient (filler binder disintegrant) with improved flowability from GRS by the co-precipitation method.

Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids.

The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline-citric acid (THPCIT) cocrystal formation during the granulation process, thereby reducing the number of operations. In addition, the influence of granulation liquid was investigated.

Evaluation of using spray-dried glutinous rice starch as a direct compression hydrophilic matrix tablet.

Background: Our previous study found that spray-dried glutinous rice starch (sGRS) is larger in size, rounder in shape and better in flowability than native GRS. It has the potential to be used for direct compression hydrophilic matrix (HM) tablets.

Objective: This study aimed to investigate the factors that affect the propranolol release from directly compressed sGRS HM tablets.

Mechanical strength, structural and hydration properties of ethanol-treated starch tablets and their impact on the release of active ingredients.

Ethanol-treated starch (ETS) shows potentiality to be used for binder of pharmaceutical tablets. This study was aimed to evaluate the mechanical strength, structural and hydration properties of ETS tablets and ETS tablets containing lauric acid and ascorbic acid and their release behavior. ETS was prepared from cassava starch at the temperatures of 80, 90, and 100 °C.

Simultaneous quantitative analysis of indomethacin and benzoic acid in gel using ultra-violet-visible spectrophotometry and chemometrics.

Background: In order to manufacture pharmaceutical products, real-time monitoring in the manufacturing process is necessary, but large equipment cost is required to achieve it.

Objective: The aim of this research is to use ultra-violet-visible spectroscopy along with chemometrics procedure to simultaneously carry out quantitative analysis of indomethacin (IMC) and benzoic acid (BA) in the gel during pharmaceutical manufacturing process.

Methods: The gel preparations contained 0.

Evaluation of swelling processes of various natural polymer matrix tablets by X-ray computed tomography and controlled drug release.

Background: The swelling properties and the drug-release sustainability of pre-gelatinized starches (𝛼-starch) tablets depend on the polymer characteristics.

Objectbs: In order to clarify the drug release form, the natural polymers (NPs) were investigated. The relationship between drug release and swelling of natural polymers (NPs), the swelling processes of various starch polymers, were investigated using a drug-release test (DRT) and X-ray computed tomography (XCT).

Rapid identification of oral solid dosage forms of counterfeit pharmaceuticals by discrimination using near-infrared spectroscopy.

Background: Since it can take an enormous amount of time and cost to discriminate counterfeit medicines by using conventional methods, counterfeit medicines has been spread in the world markets.

Objective: The purpose of this study was to develop a rapid and simple analytical method to discriminate counterfeit drugs using near infrared (NIR) spectroscopy.

Methods: Seven types of brand name tablet and generic tablets containing atorvastatin calcium sesquihydrate (AT) preparations were used as simulated counterfeit medicines.

Antibacterial Inhibitory Effects of Gel on Cariogenic Bacteria: An Study.

Aim: This study evaluated the antibacterial effects of the formulated (PG) gel against and

Materials And Methods: The PG extract was dissolved in water at 500 mg/mL. High performance liquid chromatography (HPLC) was used for identification and quantification of chemical marker punicalagin. Minimum bactericidal concentration (MBC) and time-kill assay (TKA) were investigated.

Optimization of Adhesive Pastes for Dental Caries Prevention.

Dental caries prevention products available on the market contain only remineralizing agents or antibacterial agents. This study aimed to develop adhesive pastes containing calcium phosphate and α-mangostin for dental caries prevention using the optimization technique. Calcium phosphate was used as a remineralizing agent, and extracted α-mangostin was used as an antibacterial agent.

Optimization of metronidazole sustained-release films using D-optimal design.

The aim of this study was to develop sustained-release metronidazole films for periodontal pockets using a computer-aided statistical approach. The studied independent variables were the amount of polycaprolactone, metronidazole, hydroxypropylmethyl cellulose and glyceryl monostearate. The response of interest was the cumulative percentage release of metronidazole at 1, 2, 3, 4 and 5 days.

The Antibacterial Effects of Apacaries Gel on Streptococcus mutans: An in vitro Study.

Background: New approaches for chemomechanical caries removal require effective materials with antibacterial properties for removal of infected dentin. Apacaries gel is a newly developed material comprised polyphenol from mangosteen extracts and papain mixed in gel preparation.

Aim: This study evaluated the antibacterial effects of Apacaries gel on Streptococcus mutans in vitro.

Quantitative analysis of α-mangostin in hydrophilic ointment using near-infrared spectroscopy.

The objective of this research was to quantify the α-mangostin content in mangosteen pericarp (MP) ointment as a colloidal dispersion using near-infrared (NIR) spectroscopy. Various concentrations of MP (IP and EP) ointments containing both internal and external pericarps were prepared and the NIR spectra of these ointments were measured. The NIR spectrum of each ointment was correlated with α-mangostin concentration by partial least square (PLS) regression.

Comparison of Marginal Microleakage of Glass Ionomer Restorations in Primary Molars Prepared by Chemo-mechanical Caries Removal (CMCR), Erbium: Yttrium Aluminum-Garnet (Er:YAG) Laser and Atraumatic Restorative Technique (ART).

Background: It is important to emphasize that the aspects of pretreatment techniques, as well as the composition and mechanism of adhesion, may decisively influence the effectiveness of the restorative materials in sealing cavity margins and preventing marginal leakage.

Aims: This study assessed the in vitro influence of surface preparation techniques on the microleakage of glass ionomer restorations in primary teeth.

Materials And Methods: The study groups were divided into three different techniques: (1) The chemomechanical caries removal (CMCR) method using the Apacaries gel, (2) the erbium:yttrium aluminum-garnet (Er:YAG) laser method and (3) the atraumatic restorative technique (ART).

Application of NIR spectroscopy for the quality control of mangosteen pericarp powder: quantitative analysis of alpha-mangostin in mangosteen pericarp powder and capsule.

Near-infrared spectroscopy (NIR) was applied to the quantitative analysis of the concentration of alpha-mangostin (aM) in mangosteen pericarp powder (MP). The predicted results from the partial least squares chemometric method of various pretreatment data were compared to obtain the best calibration model. Two different types of containers (transparent capsules and glass vials) filled with the same samples were measured.

The physicochemical properties of a spray dried glutinous rice starch biopolymer.

Glutinous rice starch (GRS) is a biopolymer used widely in the food industry but not at all in the pharmaceutical industry. There are several ways to modify this biopolymer. Physical modification is simple and cheap because it requires no chemicals or biological agents.

Time-controlled pulse-drug release from dry-coated wax matrix tablets for colon drug delivery.

This study aimed to prepare a colon drug delivery system using dry-coated time-controlled disintegration wax matrix tablets. Indomethacin was used as a model drug. Behenic acid and lactose were used as coating materials.