Recurrent Germline BRCA2 Gene Mutation in Lithuanian Family.

Approximately 10% of all breast cancer (BC) cases are familial and caused by inheritance of mutant , or some other genes from the same DNA reparation pathway. Genetic counseling in families with cancer history is a powerful means for early cancer detection and active risk reduction through preventive interventions. This is the first report of the rare inherited frameshift-deletion mutation c.

The value of clinical prognostic factors for survival in patients with invasive urinary bladder cancer.

Unlabelled: The aim of the study was to evaluate the value of clinical prognostic factors for survival of patients with invasive urinary bladder cancer treated with radical cystectomy, chemotherapy, and radiotherapy.

Material And Methods: A total of 115 patients with invasive urinary bladder cancer were analyzed. Twenty-three patients with invasive urinary bladder cancer (pT2-T4) were treated according to the protocol of a prospective clinical study.

[Bladder preservation possibilities in the treatment of muscle-invasive bladder cancer].

Radical cystectomy is the standard of treatment for muscle-invasive transitional cell carcinoma of the bladder in European Union and in United States. During the last few decades, several clinical trials were performed with the aim to evaluate new treatment methods as an alternative to radical cystectomy for selected patient groups. According to some clinical trials, it is clear that bladder preservation is possible without compromising overall survival of these patients.