Publications by authors named "Jolie Bogart"
Article Synopsis
- Each year, 3.3 million Americans are diagnosed with non-melanoma skin cancers (NMSC), and existing treatments like surgery are invasive and costly.
- Topical treatments like 5-fluorouracil and imiquimod can have significant side effects, highlighting the need for better options.
- Research on the small molecule N-phosphonacetyl-L-aspartate (PALA) showed it to be well-tolerated and effective in reducing tumors in a mouse model, suggesting it could be a promising alternative treatment for NMSC.
Much of our understanding of GH's action stems from animal models and the generation and characterization of genetically altered or modified mice. Manipulation of genes in the GH/IGF1 family in animals started in 1982 when the first GH transgenic mice were produced. Since then, multiple laboratories have altered mouse DNA to globally disrupt Gh, Ghr, and other genes upstream or downstream of GH or its receptor.
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