Negotiating Work and Family Spheres: The Dyadic Effects of Flexible Work Arrangements on Fertility Among Dual-Earner Heterosexual Couples.

Academics and policymakers have suggested making flexible work arrangements (FWAs) the default in workplaces to promote a family-friendly workplace culture conducive to having and raising children. However, systematic research investigating how FWAs, as a long-term approach to negotiating work-family spheres, are related to fertility among dual-earner heterosexual couples is limited. Drawing on the linked-lives perspective, we theorize the relationship between FWAs and fertility among couples and potential variation depending on the interplay of both spouses' work and family characteristics.

Adolescent behavioral problems, preterm/low birth weight children and adult life success in a prospective Australian birth cohort study.

Background: Preterm and/or low birthweight (PT/LBW) is predictive of a range of adverse adult outcomes, including lower employment, educational attainment, and mental wellbeing, and higher welfare receipt. Existing studies, however, on PT/LBW and adult psychosocial risks are often limited by low statistical power. Studies also fail to examine potential child or adolescent pathways leading to later adult adversity.

The trifecta of adulthood: Housing, partnering and childbearing trajectories.

Substantial changes in residential transitions and family formation patterns have been observed in Western societies, but less attention has been paid to the de-standardisation of adulthood pathways in East Asian contexts, where unique social, economic and cultural circumstances may produce diverse trajectories that are less explored in existing theoretical and empirical frameworks. Adopting a life course perspective, this study identifies the multi-trajectories of housing, partnering and childbearing across adulthood in Taiwan, a setting marked by high housing costs and low fertility rates. Data from the Taiwanese Panel Study of Family Dynamics 2000-2020 (N = 6,931) were used for group-based trajectory modelling, and mixed-effects multinomial regression was employed to examine the likelihood of group membership given early-life resources and social origin.

Immune and pathophysiologic profiling of antenatal coronavirus disease 2019 in the GIFT cohort: A Singaporean case-control study.

COVID-19 can be severe in pregnant women, and have adverse consequences for the subsequent infant. We profiled the post-infectious immune responses in maternal and child blood as well as breast milk in terms of antibody and cytokine expression and performed histopathological studies on placentae obtained from mothers convalescent from antenatal COVID-19. Seventeen mother-child dyads (8 cases of antenatal COVID-19 and 9 healthy unrelated controls; 34 individuals in total) were recruited to the Gestational Immunity For Transfer (GIFT) study.

Educational differentials on the transition to first birth in South Korea.

Drawing on two competing frameworks, the leader-follower model and the permanent-difference model, this study examines the educational gradient in the transition to first birth across birth cohorts in South Korea. The leader-follower model suggests that low fertility behaviour would spread from more educated women to their less educated counterparts, whereas the permanent-difference model posits that the gaps in fertility between education groups would remain distinct over time. Using nationally representative panel data of 7914 women (130,078 person-years) born between 1960 and 1984, results from discrete-time survival analysis show an initial convergence of gaps in fertility between education groups, but the gaps are now re-emerging and widening.

Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1.

Parkinson’s disease (PD) is a debilitating movement disorder characterised by the loss of dopaminergic neurons in the substantia nigra. As neuroprotective agents mitigating the rate of neurodegeneration are unavailable, the current therapies largely focus only on symptomatic relief. Here, we identified stress-inducible phosphoprotein 1 (STIP1) as a putative neuroprotective factor targeted by PD-specific autoantibodies.

New Insights into Immune-Mediated Mechanisms in Parkinson's Disease.

The immune system has been increasingly recognized as a major contributor in the pathogenesis of Parkinson's disease (PD). The double-edged nature of the immune system poses a problem in harnessing immunomodulatory therapies to prevent and slow the progression of this debilitating disease. To tackle this conundrum, understanding the mechanisms underlying immune-mediated neuronal death will aid in the identification of neuroprotective strategies to preserve dopaminergic neurons.

A framework for building cognitive process models.

The term process model is widely used, but rarely agreed upon. This paper proposes a framework for characterizing and building cognitive process models. Process models model not only inputs and outputs but also model the ongoing information transformations at a given level of abstraction.

Improving judgment accuracy by sequential adjustment.

Judging an object's value based on relevant cues can be challenging. We propose a simple method to improve judgment accuracy: Instead of estimating a value after seeing all available cues simultaneously, individuals view cues sequentially, one after another, making and adjusting their estimate at each step. The sequential procedure may alleviate computational difficulties in cue integration, leading to higher judgment accuracy.

Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.

Lipid droplets (LDs) are phylogenetically conserved cytoplasmic organelles that store neutral lipids within a phospholipid monolayer. LDs compartmentalize lipids and may help to prevent cellular damage caused by their excess or bioactive forms. FIT2 is a ubiquitously expressed transmembrane endoplasmic reticulum (ER) membrane protein that has previously been implicated in LD formation in mammalian cells and tissue.

Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion.

Lipid droplets (LDs) were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins.

Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.

Triglycerides within the cytosol of cells are stored in a phylogenetically conserved organelle called the lipid droplet (LD). LDs can be formed at the endoplasmic reticulum, but mechanisms that regulate the formation of LDs are incompletely understood. Adipose tissue has a high capacity to form lipid droplets and store triglycerides.