Investigating the use of endogenous quinoid moieties on carbon fibre as means of developing micro pH sensors.

The redox profile obtained from electrochemically oxidised carbon fibre was exploited as a foundation from which to design a reusable pH probe. X-ray photoelectron spectroscopy of the surface after anodisation revealed an increase in the population of endogenous quinone moieties. Square wave voltammograms recorded in various buffer solutions (pH3-9) yielded a distinct and unambiguous oxidation process through which to ascribe the peak potential - with the latter found to shift in a sub-Nernstian (-0.

Nanostructuring carbon fibre probes for use in central venous catheters.

A carbon fibre probe is described which utilises the oxidation of an endogenous biomarker to provide diagnostic information on the condition of intravascular access lines. The probe surface was modified through anodic oxidation to provide a high selectivity towards urate which was used as a redox probe through which the pH could be determined. A Nernstian response (-60 mV/pH) was obtained which was free from the interference of other redox species common to biofluids.

A disposable sensor for point of care wound pH monitoring.

The development of a disposable pH sensor for the point of care monitoring of wound pH is described. The system exploits the pH dependence of an endogenous biomarker (urate) to yield an unambiguous signal. The sensor responses have been characterised and the responses validated in whole blood.