Resting and exercise energy metabolism in weight-reduced adults with severe obesity.

Objective: To determine effects of physical activity (PA) with diet-induced weight loss on energy metabolism in adults with severe obesity.

Methods: Adults with severe obesity (n = 11) were studied across 6 months of intervention, then compared with controls with less severe obesity (n = 7) or normal weight (n = 9). Indirect calorimetry measured energy metabolism during exercise and rest.

U-500 insulin as a component of basal bolus insulin therapy in type 2 diabetes.

Background: Changes in hemoglobin A1c (A1C), weight, and total daily insulin dose (TDD) were investigated following initiation of insulin U-500 (U500) alone or as part of a basal/bolus insulin (BBI) regimen.

Subjects And Methods: Records of patients with type 2 diabetes who were prescribed U500 were retrospectively reviewed. Logistic regression analysis was used to investigate relationships between changes in A1C and use of U500 alone or as BBI.