Pulmonary embolism and reactivation of tuberculosis during everolimus therapy in a kidney transplant recipient.

Background: Proliferation signal inhibitors (PSIs) - sirolimus and everolimus - are commonly used in kidney transplant patients with co-existing neoplasms. These drugs may have prothrombotic activity, but aside from use in interventional cardiology, their clinical relevance has not been confirmed. In contrast to pulmonitis, an association of everolimus therapy with pulmonary embolism has never been documented.