Publications by authors named "Jolanda A F Piepers"
Radiation therapy (RT) is a common treatment for lung cancer. Still, it can lead to irreversible loss of pulmonary function and a significant reduction in quality of life for one-third of patients. Preexisting comorbidities, such as chronic obstructive pulmonary disease (COPD), are frequent in patients with lung cancer and further increase the risk of complications.
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- - The study focuses on glioblastoma (GBM), a dangerous brain cancer, and how patient-derived cancer organoids (PGOs) can help understand how tumors respond to treatments and why they sometimes don't work.
- - Researchers created PGOs from GBM samples and tested how they respond to a cancer drug called temozolomide (TMZ), finding that different organoids had different reactions based on their unique genetic traits.
- - The results show that PGOs can keep the important genetic differences of the tumors and could be used in the future to tailor treatments to individual patients and discover new drug targets.
The infiltrative behavior of diffuse gliomas severely reduces therapeutic potential of surgical resection and radiotherapy, and urges for the identification of new drug-targets affecting glioma growth and migration. To address the potential role of protein tyrosine phosphatases (PTPs), we performed mRNA expression profiling for 91 of the 109 known human PTP genes on a series of clinical diffuse glioma samples of different grades and compared our findings with in silico knowledge from REMBRANDT and TCGA databases. Overall PTP family expression levels appeared independent of characteristic genetic aberrations associated with lower grade or high grade gliomas.
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