Personality and cardiovascular mortality risk: a multi-cohort analysis in individuals with and without pre-existing cardiovascular disease.

This study investigated the associations between personality traits of the Five Factor Model and cardiovascular mortality, with a specific focus on whether pre-existing cardiovascular conditions modified these associations. We used data from 43,027 participants across five cohort studies: Health and Retirement Study (HRS); Wisconsin Longitudinal Study (WLS); National Social Life, Health, and Aging Project (NSHAP); Midlife in the United States (MIDUS); Household, Income, and Labour Dynamics in Australia (HILDA) with a mean age 55.9 years and 6493 individuals with pre-existing cardiovascular disease.

Reporting heterogeneity in the associations between personality and health problems: Anchoring self-reports with health vignettes.

Associations between personality and self-reported health problems may be biased by reporting heterogeneity, that is, tendency to rate the severity of the same health problem differently. This study used hypothetical health vignettes to examine the magnitude of such heterogeneity. Participants were from Health and Retirement Study (HRS;  = 3950; mean age 65 years, range from 30 to 97) and Wisconsin Longitudinal Study (WLS;  = 8664; mean age 64 years, range from 34 to 87).

Temporal Associations Between Specific Depressive Symptoms and Physical Inactivity in Middle Aged and Older Adults.

Being physically inactive can worsen mental health. Physical inactivity and depression are associated, but the temporal precedence and underlying mechanism are unclear; symptoms affecting future physical activity may not be the same symptoms as those associated with and affected by it. We used large European cohort (Survey of Health, Ageing, and Retirement in Europe, SHARE, N = 124, 526) to study temporal associations between physical inactivity and individual depressive symptoms.

Obesity and risk of diseases associated with hallmarks of cellular ageing: a multicohort study.

Background: Ageing hallmarks, characterising features of cellular ageing, have a role in the pathophysiology of many age-related diseases. We examined whether obesity is associated with an increased risk of developing such hallmark-related diseases.

Methods: In this multicohort study, we included people aged 38-72 years with data on weight, height, and waist circumference measured during a clinical examination at baseline between March 13, 2006, and Oct 1, 2010, from the UK Biobank with follow-up until Nov 12, 2021.

Sociodemographic risk factors for the persistence of harmful alcohol use: a pooled analysis of prospective cohort studies.

Purpose: Previous research suggests several sociodemographic risk factors for the persistence of harmful alcohol use. However, the evidence is limited due to short follow-up times, retrospective reporting and samples comprising only people with alcohol dependence. We pooled data from six prospective cohort studies to systematically evaluate whether the sociodemographic risk factors differ between the incidence and persistence of harmful alcohol use.

Impact of physical and sexual abuse on risk of hospitalisations for physical and mental illnesses: insights from two large prospective cohort studies.

Background: Physical abuse can lead to severe health consequences that extend beyond immediate harm. We explored the associations of physical abuse experienced during childhood and adulthood with a wide range of adult health conditions requiring hospital treatment.

Methods: We utilised data from a sub-cohort of 157,366 UK Biobank participants (46.

Variants in tropomyosins TPM2 and TPM3 causing muscle hypertonia.

Patients with myopathies caused by pathogenic variants in tropomyosin genes TPM2 and TPM3 usually have muscle hypotonia and weakness, their muscle biopsies often showing fibre size disproportion and nemaline bodies. Here, we describe a series of patients with hypercontractile molecular phenotypes, high muscle tone, and mostly non-specific myopathic biopsy findings without nemaline bodies. Three of the patients had trismus, whilst in one patient, the distal joints of her fingers flexed on extension of the wrists.

Role of the repeat expansion size in predicting age of onset and severity in RFC1 disease.

RFC1 disease, caused by biallelic repeat expansion in RFC1, is clinically heterogeneous in terms of age of onset, disease progression and phenotype. We investigated the role of the repeat size in influencing clinical variables in RFC1 disease. We also assessed the presence and role of meiotic and somatic instability of the repeat.

Physical activity and specific symptoms of depression: A pooled analysis of six cohort studies.

Background: The association between physical activity (PA) and depression is well-established, but the details that explain this association remain elusive. We examined whether PA is differentially associated with specific symptoms of depression (e.g.

A retrospective study of accuracy and usefulness of electrophysiological exercise tests.

Objectives: This study aimed to determine the usefulness of electrophysiological exercise tests. The significance of slightly abnormal exercise tests was also examined.

Methods: We identified all the patients who had undergone exercise testing between February 2007 to June 2022 in Tampere University Hospital, Finland.

Loneliness and cognitive function in older adults: Longitudinal analysis in 15 countries.

This study aims to evaluate the directionality of the association between loneliness and cognitive performance in older adults, accounting for confounding factors. Data were from 55,662 adults aged ≥ 50 years who participated in Waves 5-8 of the Survey of Health, Ageing and Retirement in Europe (SHARE). Loneliness was assessed with the Three-Item Loneliness Scale (TILS) and with a one-item direct question.

Variant Associated With a Myalgic Myopathy Phenotype.

Background And Objectives: This study aimed to characterize the phenotype of a novel myalgic myopathy encountered in a Finnish family.

Methods: Four symptomatic and 3 asymptomatic individuals from 2 generations underwent clinical, neurophysiologic, imaging, and muscle biopsy examinations. Targeted sequencing of all known myopathy genes was performed.

Distal myopathy.

Distal myopathies are a group of genetic, primary muscle diseases. Patients develop progressive weakness and atrophy of the muscles of forearm, hands, lower leg, or feet. Currently, over 20 different forms, presenting a variable age of onset, clinical presentation, disease progression, muscle involvement, and histological findings, are known.

Associations between early family environment and ideal number of children.

Childhood family is vital for the formation of fertility preferences and attitudes towards family life. Yet previous studies mainly focused on structural aspects of the family, whereas the role of perceptions of one's family in relation to fertility preferences remained largely understudied. This study examined how different aspects of the early family environment (i.

Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland.

Introduction: The incidence of amyotrophic lateral sclerosis (ALS) worldwide is approximately 1-2.6/1,000,000 and prevalence is 5-6/100,000. ALS has been suggested to be relatively common in Finland, but epidemiological information on the subject is scarce and outdated.

Health trajectories of individuals who quit active religious attendance: analysis of four prospective cohort studies in the United States.

Purpose: To examine whether trajectories of health (depressive symptoms, psychological wellbeing, self-rated health, and body mass index) and health behaviors (smoking, heavy alcohol consumption, physical inactivity, and cannabis use) changed for individuals who first reported at least monthly religious attendance and then in subsequent study waves reported no active religious attendance.

Methods: Data were from four cohort studies from the United States collected between 1996 and 2018: National Longitudinal Survey of 1997 (NLSY1997); National Longitudinal Survey of Young Adults (NLSY-YA); Transition to Adulthood Supplement of the Panel Study of Income Dynamics (PSID-TA); and Health and Retirement Study (HRS) with a total n = 6592 individuals and 37,743 person-observations.

Results: None of the 10-year trajectories of health or health behaviors changed for the worse after the change from active to inactive religious attendance.

Obesity as a causal risk factor for depression: Systematic review and meta-analysis of Mendelian Randomization studies and implications for population mental health.

Background/objectives: Obesity has been associated with elevated risk of depression. If this association is causal, the increasing obesity prevalence might lead to worsening population mental health, but the strength of the causal effect has not been systematically evaluated.

Subjects/methods: The current study provides a systematic review and meta-analysis of studies examining associations between body mass index and depression using Mendelian randomization with multiple genetic variants as instruments for body mass index.

Association Between Depression and Physical Conditions Requiring Hospitalization.

Importance: Depression is associated with an increased risk of physical illness, but the most common causes of hospitalization among people with depression are unclear.

Objective: To examine the association of depression with an array of physical conditions requiring hospital treatment.

Design, Setting, And Participants: In this outcomewide prospective multicohort study, primary analysis was based on data from the UK Biobank, a population-based study in the United Kingdom.

Predicting work disability among people with chronic conditions: a prospective cohort study.

Few risk prediction scores are available to identify people at increased risk of work disability, particularly for those with an existing morbidity. We examined the predictive performance of disability risk scores for employees with chronic disease. We used prospective data from 88,521 employed participants (mean age 43.

The crucial role of titin in fetal development: recurrent miscarriages and bone, heart and muscle anomalies characterise the severe end of titinopathies spectrum.

Background: Titin truncating variants (TTNtvs) have been associated with several forms of myopathies and/or cardiomyopathies. In homozygosity or in compound heterozygosity, they cause a wide spectrum of recessive phenotypes with a congenital or childhood onset. Most recessive phenotypes showing a congenital or childhood onset have been described in subjects carrying biallelic TTNtv in specific exons.

Anoctamin-5 related muscle disease: clinical and genetic findings in a large European cohort.

Anoctamin-5 related muscle disease is caused by biallelic pathogenic variants in the anoctamin-5 gene (ANO5) and shows variable clinical phenotypes: limb-girdle muscular dystrophy type 12 (LGMD-R12), distal muscular dystrophy type 3 (MMD3), pseudometabolic myopathy or asymptomatic hyperCKaemia. In this retrospective, observational, multicentre study we gathered a large European cohort of patients with ANO5-related muscle disease to study the clinical and genetic spectrum and genotype-phenotype correlations. We included 234 patients from 212 different families, contributed by 15 centres from 11 European countries.

Associations between specific depressive symptoms and psychosocial functioning in psychotherapy.

Background: Psychotherapy for depression aims to reduce symptoms and to improve psychosocial functioning. We examined whether some symptoms are more important than others in the association between depression and functioning over the course of psychotherapy treatment.

Methods: We studied associations between specific symptoms of depression (PHQ-9) and change in social and occupational functioning (SOFAS), both with structural equation models (considering liabilities of depression and each specific symptom) and with logistic regression models (considering the risk for individual patients).