Publications by authors named "Jojo Reyes"
Article Synopsis
- The cohesin protein complex helps organize chromosomes into specific domains but its biological importance is unclear.
- This study highlights that cohesin is essential for the differentiation and function of dendritic cells, particularly in antigen presentation and IL-12 secretion.
- It also shows that the interplay between cohesin and the transcription factor IRF8 influences chromatin structure, gene expression, and the activation of dendritic cells.
Globally, cryptosporidiosis is a leading cause of childhood diarrheal disease and is a major risk factor for malnutrition and impairment of growth and cognitive development. In this issue of Cell Host & Microbe, Maradana et al. identify a target for dietary enhancement of innate immune defenses against cryptosporidiosis.
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- Infections can lead to weight loss due to changes in behavior and metabolism, known as sickness behaviors, which can either help or hinder survival depending on the pathogen involved.
- Recent research highlights the role of the cytokine GDF-15, which leads to weight loss by suppressing appetite and affecting metabolism, particularly during infections like Toxoplasma gondii.
- This study explored how GDF-15 is regulated during T. gondii infections, finding that weight loss occurs alongside increased levels of GDF-15 and IFN-γ, suggesting a complex interaction between immune responses and metabolic changes in the host.
Growth differentiation factor 15 (GDF-15) is a cytokine that is widely used as a biomarker for the severity of diverse disease states. It also has been shown to play a protective role after tissue injury and to promote a negative energy balance during obesity and diabetes. In addition to its metabolic effects, GDF-15 also regulates the host's immune responses to infectious and noninfectious diseases.
View Article and Find Full Text PDFToxoplasma gondii exploits the migratory properties of monocytes and dendritic cells to promote tissue dissemination. Recently, ten Hoeve et al. reported that the parasite effector protein GRA28 conspires with host chromatin modifiers to confer dendritic cell-like features that convert sessile macrophages into migratory cells that transport infection to distal organs.
View Article and Find Full Text PDFMore than 2 billion people worldwide are infected with helminths. Thus, it is possible for individuals to experience concomitant infection with helminth and intracellular microbes. Although the helminth-induced type 2 response can suppress type 1 proinflammatory responses required for the immunity against intracellular pathogens in the context of a coinfection, conflicting evidence suggest that helminth infection can enhance antimicrobial immunity.
View Article and Find Full Text PDFResistance and tolerance are vital for survivability of the host-pathogen relationship. Virulence during infection in mice is mediated by parasite kinase-dependent antagonism of IFN-γ-induced host resistance. Whether avirulence requires expression of parasite factors that induce host tolerance mechanisms or is a default status reflecting the absence of resistance-interfering factors is not known.
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