Objective: To provide insight into the motives for hospital self-referral during office hours and the barriers deterring general practitioner (GP) consultation with a primary care request.
Setting: People who self-referred at a Daytime General Practice Cooperative (GPC) in two hospitals in The Hague, The Netherlands.
Participants: A total of 44 people who self-referred were interviewed in two hospitals.
Unlabelled: In this large population-based cohort study, variants in ESR2 were associated with increased risk of vertebral and incident fragility fracture in postmenopausal women. Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture.
Introduction: Osteoporosis is a complex disease with strong genetic influence, but the genes involved are ill-defined.