Rhodamine B oxidation promoted by P450-bioinspired Jacobsen catalysts/cellulose systems.

In this work, we investigated the preparation of P450-bioinspired Mn(iii)-Schiff base complexes supported on DEAE-cellulose ((,)-Jacobsen/Cell(NEt) and (,)-Jacobsen/Cell(NEt), respectively) to oxidize substrates of biological interest. Catalysts were characterized by several physical techniques. UV-Vis spectroscopy with diffuse reflectance (DR/UV-Vis) analysis featured peculiar electronic transitions for both complexes.

Cytotoxicity, cellular uptake, and subcellular localization of a nitrogen oxide and aminopropyl-β-lactose derivative ruthenium complex used as nitric oxide delivery agent.

This work investigates how the luminescent ruthenium-nitrite complexes cis-[Ru(py-bodipy)(dcbpy)(NO)](PF) (I) and cis-[Ru(py-bodipy)(dcbpy-aminopropyl-β-lactose)(NO)](PF) (II) behave toward the melanoma cancer cell line B16F10. The chemical structure and purity of the synthesized complexes were analyzed by UV-Visible and FTIR spectroscopy, MALDI, HPLC, and H NMR. Spectrofluorescence helped to determine the fluorescence quantum yields and lifetimes of each of these complexes.

Metabolism evaluation of the anticancer candidate AC04 by biomimetic oxidative model and rat liver microsomes.

Jacobsen reagents, in the presence of monooxygen donors, appear as an alternative to produce metabolites from biological active compounds. This reaction may mimic the oxidation and oxygenation reactions of cytochrome P450 (CYP450) enzymes upon various drugs and biologically active compounds. Acridines represent a well-known group of polyaromatic compounds capable of acting as DNA intercalating agents.