Publications by authors named "Johns T Johnson"
Background And Objectives: Marked changes in the hypothalamic-pituitary axis have been documented in patients with traumatic brain injury (TBI). These enduring endocrine challenges could significantly influence the physical and psychological outcomes thereby impacting overall recovery. This study aimed to determine the prevalence and types of endocrine dysfunction in men with chronic TBI and to determine the association of endocrine dysfunction with clinical outcomes.
View Article and Find Full Text PDFChronic consumption of a large quantity of alcohol often results in the disruption of the communication between the nervous, endocrine and immune systems leading to profound and serious consequences at the physiological and behavioral levels. The overall impact of excessive alcohol consumption on bone health, metabolic profile and body composition, especially at moderate levels, is not well understood. Chronic excessive alcohol consumption adversely affects bone health through multiple mechanisms leading to low bone mass.
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- The study found that postmenopausal women with femoral neck fractures in southern India had significantly worse proximal hip geometry and trabecular bone scores compared to those without fractures.
- The research included 90 women with fractures and 90 age-matched controls, revealing a higher prevalence of osteoporosis and degraded bone microarchitecture among the women with fractures.
- Key factors linked to femoral neck fractures included osteoporosis at the femoral neck, lower cross-sectional moment of inertia, and higher buckling ratio in the hip structure.
Familial hypercholesterolaemia (FH) is an autosomal dominant inherited disorder of lipoprotein metabolism caused by defects in the low-density lipoprotein receptor (LDLR) gene. It is characterized by high low-density lipoprotein (LDL) cholesterol levels, premature cardiovascular disease (CVD), and tendon xanthomas. We present the case of a 26-year-old gentleman who presented with multiple nodular eruptions over the extensor aspects of upper and lower limbs and was diagnosed as FH on the basis of positive family history, typical lipid profile abnormalities, and biopsy of the nodule consistent with tendon xanthomas.
View Article and Find Full Text PDFWe present the case of a 45-year-old lady with long standing hypothyroidism who was euthyroid on replacement for many years, but stopped responding even to supraphysiological doses of LT4 since the last five years. She complained of abdominal discomfort, bloating, and nausea. She did not have diarrhea or weight loss.
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- * These tumors can sometimes be misdiagnosed, which can lead to unexpected high blood pressure crises during surgery.
- * The case discussed involves a 44-year-old woman with urinary bladder paraganglioma who had symptoms like hypertension and fainting; she was treated with medications before successfully undergoing surgery to remove the tumor.