Digital image analysis of gland-to-stroma ratio by CD10 objectively differentiates between low-grade endometrioid carcinoma and atypical hyperplasia on endometrial biopsy.

Distinguishing between endometrial atypical hyperplasia/endometrial intraepithelial neoplasia (EAH/EIN) and grade 1 endometrial endometrioid carcinoma (EEC) requires the evaluation of gland-to-stromal ratio, presence of stromal invasion, extent of epithelial proliferation and nuclear alterations. In small biopsies, stromal invasion may not always be sampled, so other features become more important. However, assessing of some of these features may be subjective.